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Domestic chondroitin sulfate production accounted for 80% of the world, the prospect is promising

Date:2022-07-01    Hits:288

Chondroitin sulfate is an important component of articular cartilage. In industrial application, chondroitin sulfate is mainly extracted from cartilage of cattle, pigs, poultry and fish. Chondroitin sulfate preparation mainly tablet and injection, used in arthritis, eye drops, etc., to improve the elderly degenerative arthritis, rheumatoid arthritis has a certain effect, improve joint problems.

Aging populations push up demand for chondroitin sulfate

It is predicted that by 2050, the population aged 60 and above in China will reach 483 million, and there will be more than 100 million patients with osteoarthritis in China. Degenerative arthritis in the elderly is a multiple disease. Currently, non-steroidal anti-inflammatory drugs are mainly used clinically, but their side effects cannot be ignored. Chondroitin sulfate and glucosamine are two natural compounds that may be used to repair joints and slow their progressive degradation. Practice has proved that chondroitin sulfate has certain effects on the improvement of senile degenerative arthritis and rheumatoid arthritis, so the market is rapidly rising momentum. With the increase of aging population base, the demand for health care products increases. The huge population provides a broad market prospect for chondroitin sulfate and other health care food markets, and the industry has a promising future.

Foreign market demand boosts domestic chondroitin sulfate production

Chondroitin sulfate used in Europe and the United States mainly comes from local animals such as cattle and sheep. Later due to & LDquo; Mad cow disease & throughout; Europe and the United States and other countries began to purchase chondroitin sulfate in large quantities from pig cartilage processing in the global market. As the world's largest pig raising country, China has 406.5 million pigs at the end of 2020 according to the National Bureau of Statistics. With its resource advantage, China has rapidly become the world's core procurement place for chondroitin sulfate.

Application of enzymolysis technology in the production of chondroitin sulfate

The most commonly used method in China is to extract chondroitin sulfate by combining dilute alkali or concentrated alkali with enzymolysis technology. The traditional process is: cartilage cooking alkali extraction, enzyme hydrolysis, hydrogen peroxide decolorization, alcohol precipitation, refining the finished product of chondroitin sulfate.

In the enzymatic hydrolysis process, pancreas is the main enzyme preparation. The crude pancreatic enzyme prepared from pancreas contains a variety of enzymes, including amylase and lipase, in addition to a variety of proteases, which is conducive to hydrolysis and reduce the cost. However, there are pancreatic enzymes or stability, which is not conducive to standard chemogenesis. Therefore, some manufacturers use alkaline protease or special compound enzyme products to achieve standardized production and achieve the purpose of reducing costs.